Located in Oconee and Pickens counties in Upstate, SC, beautiful Lake Keowee is know for its pristine water, private alcoves, and uncrowded shores. Keowee has 18,500 acres of water and a 300-mile shoreline and is a spacious, popular location for boating, fishing, water-skiing, and camping. With mountain views and year-round boating, Lake Keowee is a unique recreational area. Lake Keowee covers Keowee Town, site of the former capital of the Lower Cherokee Nation.